Labrinth, Kasabian and Rizzle Kicks are some of the names lined up for the 2013 Teenage Cancer Trust gigs.
The acts have been chosen by ex-Oasis star Noel Gallagher, who is curating next year's shows at London's Royal Albert Hall.
Other performers on the bill include Primal Scream, Blur's Damon Albarn and Graham Coxon, as well as comedy stints from Russell Brand and Noel Fielding.
The shows wil take place from Tuesday 19 to Sunday 24 March.
Noel Gallagher, who is also due to perform, said it was "an honour" to be put in charge of the concerts.
"I've always been more than pleased to lend my support over the years," said the 45-year-old singer.
"It's also now a charity that is very close to the hearts and minds of dozens of acts in the world of music."
The final show of the series will feature Labrinth and Rizzle Kicks on the same bill.
Support acts for all the shows will be announced soon.
Since it first began in 2000, the Teenage Cancer Trust series has raised £15 million for teenagers and young people with cancer.
Last year's event was headlined by the likes of Example, Jessie J and Florence + the Machine.
Tickets go on sale on 7 December at 9.30am.